ALS Gene Library

Other Established ALS Genes

Additional genes require careful source review because the strength and type of evidence can differ between genes.

More than 40 genes have been associated with ALS or increased ALS risk, although the strength of evidence differs between genes.

Four major genes—C9orf72, SOD1, TARDBP, and FUS—account for a large proportion of genetically explained familial ALS in populations of European ancestry.

Sources: ALS Genes and Mutations

Additional gene index
GeneEntry status
ALS2Source-reviewed classification required for gene-specific claims.
ANGSource-reviewed classification required for gene-specific claims.
ANXA11Source-reviewed classification required for gene-specific claims.
CHCHD10Source-reviewed classification required for gene-specific claims.
CHMP2BSource-reviewed classification required for gene-specific claims.
DCTN1Source-reviewed classification required for gene-specific claims.
FIG4Source-reviewed classification required for gene-specific claims.
GLE1Source-reviewed classification required for gene-specific claims.
HNRNPA1Source-reviewed classification required for gene-specific claims.
KIF5ASource-reviewed classification required for gene-specific claims.
MATR3Source-reviewed classification required for gene-specific claims.
NEK1Source-reviewed classification required for gene-specific claims.
OPTNSource-reviewed classification required for gene-specific claims.
PFN1Source-reviewed classification required for gene-specific claims.
SETXSource-reviewed classification required for gene-specific claims.
SPG11Source-reviewed classification required for gene-specific claims.
SQSTM1Source-reviewed classification required for gene-specific claims.
UBQLN2Source-reviewed classification required for gene-specific claims.
VAPBSource-reviewed classification required for gene-specific claims.
VCPSource-reviewed classification required for gene-specific claims.

Sources & Further Reading

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This information is for education and does not replace individualized medical advice, genetic counseling, diagnosis, or treatment. Genetic risk, penetrance, and testing implications can differ by gene, variant, family, and individual.

Last reviewed: 09-30-2026

Medical information should be reviewed periodically as genetic research and clinical trials change.