National Library of Medicine / GeneReviews
Amyotrophic Lateral Sclerosis Overview
A direct source for reviewing the medical, genetic, research, or policy information discussed on this page.
Visit sourceALS Genetics & Gene Carriers
ALS Gene Library
ALS is genetically heterogeneous. Different ALS-associated genes can differ in inheritance, penetrance, age of onset, clinical presentation, ALS/FTD overlap, disease progression, available treatments, and research opportunities.
Discoveries in one ALS gene do not automatically apply to every genetic form of ALS.
Gene entry
C9orf72
Explore the sourced overview, inheritance, clinical context, treatments, research, and references for this entry.
Open gene page Gene entrySOD1
Explore the sourced overview, inheritance, clinical context, treatments, research, and references for this entry.
Open gene page Gene entryFUS
Explore the sourced overview, inheritance, clinical context, treatments, research, and references for this entry.
Open gene page Gene entryTARDBP
Explore the sourced overview, inheritance, clinical context, treatments, research, and references for this entry.
Open gene page Gene entryTBK1
Explore the sourced overview, inheritance, clinical context, treatments, research, and references for this entry.
Open gene page Gene entryOther established ALS genes
Explore the sourced overview, inheritance, clinical context, treatments, research, and references for this entry.
Open gene pageGene detail fields
What each gene page covers
Each page brings together the fields readers need to compare gene-specific information without treating one gene as representative of all ALS.
- Gene name
- Full gene name
- Associated conditions
- ALS / FTD relationship where applicable
- Typical inheritance pattern
- What is known about penetrance
- Clinical presentation
- Genetic testing considerations
- Biomarkers
- Available treatments
- Clinical trials
- Presymptomatic research
- Current research
- Key research institutions/studies
- References / sources
- Last reviewed date
Sources & Further Reading
These source cards link directly to the original material. External websites open in a new tab.
The ALS Association
ALS Genes and Mutations
Accessible overview of ALS genetics and gene-focused research topics.
Visit sourceThis information is for education and does not replace individualized medical advice, genetic counseling, diagnosis, or treatment. Genetic risk, penetrance, and testing implications can differ by gene, variant, family, and individual.
Last reviewed: 09-30-2026
Medical information should be reviewed periodically as genetic research and clinical trials change.