Emory ALS genetics and biomarker research

Overview

Official title

Emory ALS Genetics, Biomarkers, and Disease Mechanisms Research

Brief title

Emory ALS genetics and biomarker research

Registration type

Research program

NCT number

Not stated

Status

Recruitment status requires confirmation

Study category

Genetic, Biomarker, Natural history, Biospecimen, Other research

Sponsor / center

Emory University

Research center

Emory ALS Center

Collaborators

Not stated in the official study record.

Study type

Research program

Phase

Not applicable / observational

Enrollment

Not stated in the official study record.

Start date

Not stated in the official study record.

Primary completion date

Not stated in the official study record.

Estimated / actual completion date

Not stated in the official study record.

Last source update

Not stated in the official study record.

What is being studied?

The official Emory research page describes work comparing DNA, RNA, and protein expression, studying healthy people who carry ALS-associated mutations, measuring cryptic exons as possible biomarkers, and using genomics, proteomics, cell modeling, and animal models.

Intervention(s)

Not stated in the official study record.

Who may be eligible?

This is a simplified summary. The official study team or research center determines eligibility.

Population / disease status

Diagnosed ALS, Presymptomatic gene carrier, Blood relative, Healthy control

Diagnosis / conditions

Amyotrophic lateral sclerosis, Genetic ALS

Age

Not stated in the official study record. to Not stated in the official study record.

Disease duration

Not stated in the official study record.

Respiratory criteria

Not stated in the official study record.

ALSFRS-R criteria

Not stated in the official study record.

Genetic criteria

The official eligibility criteria include language relevant to this topic; review the full criteria below.

Medication requirements

Not stated in the official study record.

Official center study description

The official Emory research page describes work comparing DNA, RNA, and protein expression, studying healthy people who carry ALS-associated mutations, measuring cryptic exons as possible biomarkers, and using genomics, proteomics, cell modeling, and animal models.

Genetics

Gene-specific study?

Not stated

Gene or variant

Other specified ALS gene

Genetic test required?

Not stated

Known carrier required?

Not stated

Confirmed pathogenic variant required?

Not stated

Presymptomatic carriers eligible?

Not stated

At-risk relative eligible?

Not stated

Genetic test provided?

Not stated

Genetic counseling provided?

Not stated

Results returned / offered?

Not stated

Family history required?

Not stated

Study design

Randomized?

Not stated in the official study record.

Allocation

Not stated in the official study record.

Intervention model

Not stated in the official study record.

Masking

Not stated in the official study record.

Placebo

Not stated in the official study record.

Primary purpose

Not stated in the official study record.

Endpoints

Primary outcome measures

Not stated in the official study record.

Secondary outcome measures

Not stated in the official study record.

A biomarker outcome should not automatically be interpreted as a clinical outcome.

Locations

Contact

Central contact: Not stated in the official study record.